Herpes Simplex Virus: Treatment a. Management of neonates with symptomatic/proven HSV disease i. Intravenous acyclovir (20 mg/kg/dose...

Herpes Simplex Virus (HSV) 1. Background a. HSV type 2 is the most common cause of neonatal herpes disease. b. Transmission is usually...

Targeted therapies: 1. Inhaled nitric oxide 2. Prostacyclin analogs – (Prostacyclin produces vasodilation by stimulating cyclic adenosine...

1. Goals: Maintain systemic blood pressure to overcome right-to-left shunt and decrease pulmonary vascular resistance to facilitate...

B. Clinical Presentation 1. Symptoms – Evidence of respiratory distress, tachypnea, oxygen desaturation, cyanosis 2. Oxygenation index...

A. Background 1. Characterized by elevated pulmonary pressures after birth in conjunction with a right-to-left shunt across the ductus...

Antibiotics i. The goals are to prevent ongoing GI mucosal injury, prevent translocation of enteric bacteria into the bloodstream, and...

Background 1. Pathogenesis is multifactorial. a. Immaturity of the GI tract is the most important factor. i. Immaturity results in...

Treatment 1. Supportive care, including fluid restriction and respiratory support, may be sufficient to manage the symptoms of PDA...

Clinical Presentation 1. Symptoms – Murmur, hyperactive precordium, bounding pulses, widened pulse pressure, hypotension, worsening...