PERSISTENT PULMONARY HYPERTENSION OF THE NEWBORN

Targeted therapies:

1. Inhaled nitric oxide

2. Prostacyclin analogs – (Prostacyclin produces vasodilation by stimulating cyclic adenosine monophosphate(cAMP)]production:

a. Epoprostenol

b. Iloprost

3. Phosphodiesterase (PDE) inhibitors-

a. Sildenafil

b. Milrinone

4. Endothelin receptor antagonists-

a. Bosentan

b. Ambrisentan